Pioneering drugs for overactive bladder and detrusor overactivity: Ongoing research and future directions
Pioneering drugs for overactive bladder and detrusor overactivity: Ongoing research and future directions作者机构：Urologic Clinic Department of Surgical Sciences "Agostino Gemelli" Hospital Catholic University Medical School 00168 Rome Italy Institute of Pharmacology Catholic University Medical School 00168 Rome Italy
出 版 物：《World Journal of Obstetrics and Gynecology》 (世界妇产科杂志)
年 卷 期：2015年第4卷第2期
页 面：24-39页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Detrusor overactivity Drug therapy Lower urinary tract symptoms Overactive bladder Urinary incontinence
摘 要：The ongoing research on pioneering drug candidates for the overactive bladder （OAB） aimed to overcome the limitations of currently licensed pharmacotherapies, such as antimuscarinics, β3-adrenergic agents, and botulinum neurotoxin, has been reviewed performing a systematic literature review and web search. The review covers the exploratory agents alternative to available medications for OAB and that may ultimately prove to be therapeutically useful in the future mana-gement of OAB patients based on preclinical and early clinical data. It emerges that many alternative pharmacological strategies have been discovered or are under investigation in disease-oriented studies. Several potential therapeutics are known for years but still fnd obstacles to pass the clinical stages of development, while other completely novel compounds, targeting new pharmacological targets, have been recently discovered and show potential to translate into clinical therapeutic agents for idiopathic and neurogenic OAB syndrome. The global scenario of investigational drugs for OAB gives promise for the development of innovative thera-peutics that may ultimately prove effective as first, combined or second-line treatments within a realistic timescale of ten years.
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