Gut immune response in the presence of hepatitis C virus infection

作     者：Helal F Hetta Minesh J Mehta Mohamed Tarek M Shata 

作者机构：Department of Internal Medicine Division of Digestive DiseasesUniversity of Cincinnati Department of Medical Microbiology and Immunology Faculty of Medicine Assiut University 

出 版 物：《World Journal of Immunology》 (世界免疫学杂志)

年 卷 期：2014年第4卷第2期

页      面：52-62页

学科分类：12[管理学] 1204[管理学-公共管理] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：Supported by Egyptian Government Scholarship for Helal Hetta Merck Investigator Initiated Studies(IIS)IISP,No.40458(Shata) 

主　　题：Hepatitis C virus Colonic Treg Mucosal Im-mune regulation Liver infammation Interleukin-28B 

摘      要：Hepatitis C virus （HCV） is an important etiologic agent of hepatitis and a major cause of chronic liver infection that often leads to cirrhosis, fibrosis and hepatocel-lular carcinoma. Although, HCV is a hepatotropic virus, there is strong evidence that HCV could replicate extra-hepatic in the gastrointestinal tissue which could serve as a reservoir for HCV. The outcome of HCV infection depends mainly on the host innate and adaptive im-mune responses. Innate immunity against HCV includes mainly nuclear factor cells and activation of IFN-related genes. There is an immunologic link between the gut and the liver through a population of T-cells that are ca-pable of homing to both the liver and gut via the portal circulation. However, little is known on the role of Gut immune response in HCV. In this review we discussed the immune regulation of Gut immune cells and its as-sociation with HCV pathogenesis, various outcomes of anti-HCV therapy, viral persistence and degree of liver infammation. Additionally, we investigated the relation-ship between Gut immune responses to HCV and IL28B genotypes, which were identifed as a strong predictor for HCV pathogenesis and treatment outcome after acute infection.