依托孕烯皮下埋植避孕的临床经验和可接受性

作     者：Otero Flores J.B. Lozano Balderas M. Corté s Bonilla M. Vá zquez-Estrada L. 张旸 

作者机构：Coordinació n de Salud Reproductiva Instituto Mexicano del Seguro Social Mier y Pesado 120 Colonia Del Valle Mexico City C.P. 03100 Mexico 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第1期

页      面：55-56页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100404[医学-儿少卫生与妇幼保健学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：皮下埋植避孕 可接受性 临床经验 皮下避孕埋植剂 持续使用率 受试妇女 阴道出血情况 多中心试验 健康志愿者 副作用 

摘      要：To evaluate efficacy, adverse effects, and user continuation rate of an etonogestrel subdermal single-rod contraceptive implant. Methods: A total of 417 healthy volunteers of childbearing age were included in this multicenter trial. After implant insertion, the women were followed up during the 3 years of contraceptive action. At each visit, clinical findings, side effects, and bleeding patterns were recorded. Efficacy and continuation rates were analyzed using the Pearl Index and Kaplan-Meier life tables, respectively. Results: The observation period totaled 958.5 woman-years (27.5 months per woman). The Pearl Index score was 0. Side effects were reported by 44.4% of users, but the proportion had decreased to 16.5% by the end of the study. The continuation rate was 61.4% . The most common reason for early discontinuation (in 21.1% of the participants) was menstrual disturbances. Conclusions: Etonogestrel subdermal contraceptive implants demonstrated high efficacy and an acceptable continuation rate. Counseling potential users explicitly about the side effects will optimize patient success with this long-acting contraceptive.