Architecture of SWI/SNF chromatin remodeling complex

作     者：Zhihui Zhang Xuejuan Wang Jiyu Xin Zhenrui Ding Sheng Liu Qianglin Fang Na Yang Rui-min Xu Gang Cai 

作者机构：Hefei National Laboratory for Physical Sciences at Microscale and School of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China CAS Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesHefei 230026China National Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2018年第9卷第12期

页      面：1045-1049页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：National Natural Science Foundation of China [31170694, 31570726, 31430018] National Basic Research Program [2014CB910700] 

摘      要：The SWI/SNF complex is a large ATP-dependent chromatin remodeling complex that is highly conserved from yeast to human, which is essential for transcription regulation, genomic stability, DNA repair and many aspects of development (Kasten et al., 2011). SWI/SNF contains more than 10 subunits (M.W. 1 MDa), including a DNA-dependent ATPase subunit and several accessory subunits. Mutations in several SWI/SNF subunits have been recently identified at a high frequency in a variety of cancers (Masliah-Planchon et al., 2015). Despite the fundamental importance, the structural information of the SWI/SNF complex has been limited to only low-resolution electron microscopy (EM) reconstructions (23-30 A) without subunits localization and the lack of SWI/SNF-nucleosome structure (Smith et al., 2003; Dechassa et al., 2008).