Diagnostic Value of Sensitive Biomarkers for Early Kidney Damage in Diabetic Patients with Normoalbuminuria

作     者：Dong Zhang Qiu-Xia Han Ming-Hui Wu Wan-Jun Shen Xiao-Li Yang Jia Guo Shao-Kang Pan Zhang-Suo Liu Li Tang Guang-Yan Cai Xiang-Mei Chen Han-Yu Zhu 

作者机构：Department of NephrologyChinese People's Liberation Army General HospitalChinese People's Liberation Army Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney DiseasesBeijing 100853China Department of NephrologyThe First Affiliated Hospital of Zhengzhou UniversityResearch institute of Nephrology in Zhengzhou UniversityKey Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan ProvinceZhengzhouHenan 450052China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2018年第131卷第23期

页      面：2891-2892页

核心收录：

学科分类：10[医学] 

基　　金：the grants from the National Key R&D Program of China (No.2016YFC1305500and No.2016YFC 1305404) the National Natural Science Foundation of China (No.61471399,No.61671479,and No.81670663) the Joint Funds of National Natural Science Foundation of China and Henan Province (No.U1604284) the Special Research Project on Health Care of the Chinese People's Liberation Army (No.15BJZ35) 

主　　题：Diagnostic Value Sensitive Biomarkers Early Kidney Damage Diabetic Patients with Normoalbuminuria 

摘      要：To the Editor:Diabetic kidney disease (DKD)is the most common cause of end-stage renal disease (ESRD);however,the onset of DKD is difficult to detect.[1]When persistent microalbuminuria becomes detectable,DKD has already progressed to the third disease stage,and finding biomarkers that are more sensitive than microalbuminuria is therefore necessary to indicate kidney damage at an earlier stage of DKD.[2]Both glomerular and tubulointerstitial damages have been repeatedly demonstrated to be important factors in the pathophysiology of DKD.[3] Therefore,we investigated the expression levels of six markers closely related to the glomerulus and renal tubule.