Intravascular proliferating anaplastic lymphoma kinasepositive anaplastic large-cell lymphoma

作     者：Kohei Shiroshita Jun-ichiro Kida Kensuke Matsumoto Makiko Uemura Genji Yamaoka Yumi Miyai Reiji Haba Osamu Imataki 

作者机构：Post-Graduate Clinical Training CenterKagawa University Hospital Division of Hematology and Stem Cell TransplantationDepartment of Internal MedicineFaculty of MedicineKagawa University Department of Laboratory MedicineKagawa University Hospital Department of Diagnostic PathologyFaculty of MedicineKagawa University 

出 版 物：《World Journal of Hematology》 (世界血液学杂志)

年 卷 期：2015年第4卷第2期

页      面：10-15页

学科分类：10[医学] 

主　　题：Malignant lymphoma Cytotoxic molecule Intravascular lymphoma Anaplastic lymphoma kinase Anaplastic large-cell lymphoma 

摘      要：An 82-year-old Japanese man visited our emergency unit complaining of dyspnea. Laboratory data showed 15% atypical lymphocytes in peripheral blood which expressed the T-cell phenotype. Chest/abdominal computed tomography depicted hepatosplenomegaly and swelling of systemic lymph nodes. The patient died of advanced respiratory failure 5 d after the first occurrence of his dyspnea. At autopsy, the pathological features revealed a diffuse infiltration of large atypical lymphocytes to systemic organs including the spleen and lung. In immunohistochemical staining, these cells expressed CD30, TIA-1, anaplastic lymphoma kinase(ALK), CD5 and CD3. An advanced surface molecule analysis revealed a lack of CD54(intercellular cell adhesion molecule-1) and CD56(neural cell adhesion molecule). We observed the proliferation and infiltration of these lymphoma cells specifically at the intravascular lesions similar to intravascular lymphoma(IVL). T-cell IVL is not established as an independent clinical entity in the World Health Organization classification, and our patient s ALK-positive T-IVL in lung appears to be the first reported case.