Reducing acute respiratory distress syndrome occurrence using mechanical ventilation

作     者：Gary F Nieman Louis A Gatto Nader M Habashi 

作者机构：Department of SurgeryUpstate Medical University Biology DepartmentSUNY CortlandCortlandNY 13210United States Department of Trauma Critical Care MedicineR Adams Cowley Shock Trauma Center 

出 版 物：《World Journal of Respirology》 (世界呼吸病学杂志)

年 卷 期：2015年第5卷第3期

页      面：188-198页

学科分类：10[医学] 

主　　题：Acute respiratory distress syndrome Ventilator induced lung injury Early acute lung injury Mechanical ventilation Acute respiratory distress syndrome incidence Airway pressure release ventilation Acute respiratory distress syndrome pathophysiology 

摘      要：The standard treatment for acute respiratory distress syndrome(ARDS) is supportive in the form of low tidal volume ventilation applied after significant lung injury has already developed. Nevertheless, ARDS mortality remains unacceptably high( 40%). Indeed, once ARDS is established it becomes refractory to treatment, and therefore avoidance is key. However, preventive techniques and therapeutics to reduce the incidence of ARDS in patients at high-risk have not been validated clinically. This review discusses the current data suggesting that preemptive application of the properly adjusted mechanical breath can block progressive acute lung injury and significantly reduce the occurrence of ARDS.