Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study

作     者：Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig 

作者机构：Department of PsychiatryPsychotherapy and Psychosomatics Psychiatric Hospital University of Zurich Epidemiology Biostatistics and Prevention Institute University of Zurich Department of Psychiatry University Hospital of Lausanne Department of Neurology Bern University Hospital Clinic Barmelweid Division of Psychiatry Research University of Zurich University Children’s Hospital Zurich and Children’s Research Center and Division of Child and Adolescent Health Psychology Department of Psychology University of Zurich Department of PsychologyDivision of Clinical Psychology and Epidemiology University of Basel 

出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)

年 卷 期：2016年第6卷第4期

页      面：419-430页

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：Supported by Research grants from GlaxoSmithKline the Faculty of Biology and Medicine of Lausanne the Swiss National Science Foundation,Nos.3200B0-105993,3200B0-118308,33CSCO-122661,33CS30-139468 and 33CS30-148401 

主　　题：Neurodevelopmental disorders Mental disorders Substance abuse Childhood diseases Infectious diseases Atopic diseases Chronic inflammatory diseases Risk factors 

摘      要：AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk *** We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorde