PEG-g-poly(aspartamide-co-N,N-dimethylethylenediamino aspartamide):Synthesis,characterization and its application as a drug delivery system
PEG-g-poly（aspartamide-co-N,N-dimethylethylenediamino aspartamide）:Synthesis,characterization and its application as a drug delivery system作者机构：Key Laboratory of Molecular Engineering of Polymers (Ministry of Education) Laboratory of Advanced Materials Department of Macromolecular Science Fudan University Shanghai 200433 China
出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))
年 卷 期：2009年第19卷第10期
页 面：1305-1310页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by the China Postdoctoral Science Foundation (Grant No20080440569) Shanghai Postdoctoral Scientific Program (Grant No 09R21410900) the National Natural Science Foundation of China (Grant No50873029) the Shanghai Scientific and Technological Innovation Project (Grant No 08431902300)
主 题：PEG-g-poly(aspartamide-co-N,N-dimethylethylenediamino aspartamide) Polymeric micelle Drug delivery system Ammonium glycyrrhizinate
摘 要：PEG-g-poly(aspartamide-co-N,N-dimethylethylenediamino aspartamide)(PEG-DMEDA-PASP) was synthesized by two-step ring-opening reactions of polysuccinimide(PSI) with a-methoxy-x-amino-poly(ethylene glycol) and N,*** polymer structure was confirmed by 1H NMR and *** resultant PEG-DMEDA-PASP with ammonium glycyrrhizinate(AMG) could form polymeric micelles in aqueous *** results of transmission electron microscopy(TEM) and dynamic light scattering(DLS) measurements revealed that these polymeric micelles were spherical particles with a narrow diameter distribution and that their average diameter was ca.70 *** polymeric micelles had high-loading capacity(58%) and encapsulation efficiency(70%) for *** results of in vitro release experiments showed that these polymeric micelles possessed sustained-release effects,with a release rate of 25% within 3 h and 90% within 24 h.
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