Enantioselective addition of diethylzinc to aryl aldehydes catalyzed by 1,2,3,4-tetrahydroisoquinoline β-amino alcohol

作     者：Geng Xu[a] Zhan Zhu Liu[a] 

作者机构：[a] Key Laboratory of Bioactive Substances Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College) Ministry of Education. Institute of Materia Medica Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100050 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2010年第21卷第3期

页      面：309-311页

核心收录：

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 

主　　题：β-Amino alcohol Tetrahydroisoquinoline Diethylzinc Asymmetric addition 

摘      要：A highly effective,new chiral 1,2,3,4-tetrahydroisoquinoline catalyst 1 for the diethylzinc addition to aryl aldehydes has been *** 10 mol%of this chiral catalyst,secondary alcohols can be obtained in up to 87%yield and 99.5%ee under mild conditions.