Subversion of cellular autophagy during virus infection:Insights from hepatitis B and hepatitis C viruses
作者机构：Division of Infectious DiseasesSchool of MedicineUniversity of CaliforniaSan DiegoLa JollaCAUSA
出 版 物：《Liver Research》 (肝脏研究（英文）)
年 卷 期：2018年第2卷第3期
页 面：146-156页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：This work was supported by USA National Institutes of Health(NIH)grants AI125350 AI085087 and AI139234 to A.Siddiqui
主 题：Autophagy Hepatitis B virus(HBV) Hepatitis C virus(HCV) Endoplasmic reticulum(ER)stress Mitophagy
摘 要：Autophagy is a self-eating process,in which the damaged or excessed cell organelles and misfolded protein aggregates are removed from the cellular *** is generally thought of as a pro-survival mechanism which is not only important for balancing energy supply at times of nutrient deprivation but also in the removal of various stress stimuli to ensure *** addition to the target materials of“selforigin,autophagy can also eliminate intracellular pathogens and acts as a defense mechanism to curb *** addition,autophagy is linked to the host cell s innate immune ***,viruses have evolved various strategies to manipulate and overtake host cell machinery to establish productive replication and maintain infectious *** fact,replication of many viruses has been found to be autophagy-dependent and suppression of autophagy can potentially affect the viral ***,autophagy can either serve as an anti-viral defense mechanism or a pro-viral process that supports viral *** B virus(HBV)and hepatitis C virus(HCV)are known to co-opt cellular autophagy process as a pro-viral *** viruses also induce mitophagy,which contributes to the establishment of chronic *** review focuses on the roles of autophagy and mitophagy in the chronic liver disease pathogenesis associated with HBV and HCV infections.
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