Identification of Estrogen-associated Intrinsic Aging Genes in Chinese Han Female Skin by cDNA Microarray Technology

作     者：YAN Wei ZHAO ZhenMin ZHANG LiLi WANG DunMei YAN Li YIN NingBei WU Di ZHANG Feng 

作者机构：Plastic Surgery Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100144 China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100029 China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2011年第24卷第4期

页      面：364-373页

核心收录：

学科分类：0710[理学-生物学] 081702[工学-化学工艺] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

主　　题：Estrogen Intrinsic aging Microarray Metabolism 

摘      要：Objective Estrogens play an important role in intrinsic skin *** associated changes in global gene expression are poorly *** We used the Illumina microarray platform to obtain comprehensive gene expression profiles in female Chinese Han skin,and confirmed the data by quantitative real-time PCR （Q-RT-PCR）.Results We found 244 genes significantly related to estrogen-associated intrinsic skin aging,and some of these genes were confirmed by *** also performed functional analysis by both Gene Ontology annotation and enrichment of the Kyoto Encyclopedia of Genes and Genomes （KEGG） pathways *** functional analysis revealed 11 biological pathways （including the KEGG pathways,the mitogen-activated protein kinase signaling pathway and metabolic pathways）,that were associated with multiple cellular functions which may be involved in intrinsic skin *** This study suggests that estrogen-associated intrinsic skin aging is a complicated biological process involving many genes and pathways.