Observations on potential novel transcripts from RNA-Seq data

作     者：Chao YE Linxi LIU Xi WANG Xuegong ZHANG 

作者机构：Key Laboratory of Bioinformatics and Bioinformatics DivisionMinistry of EducationTsinghua National Laboratory for Information Science and Technology/Department of AutomationTsinghua UniversityBeijing 100084China 

出 版 物：《Frontiers of Electrical and Electronic Engineering in China》 (中国电气与电子工程前沿（英文版）)

年 卷 期：2011年第6卷第2期

页      面：275-282页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported in part by the National Natural Science Foundation of China(Grant Nos.61021063 and 60928007) 

主　　题：RNA-Seq novel transcripts next generation sequencing bioinformatics 

摘      要：With the rapid development of next generation deep sequencing technologies,sequencing cDNA reverse-transcribed from RNA molecules(RNA-Seq)has become a key approach in studying gene expression and *** RNA-Seq does not rely on annotation of known genes,it provides the opportunity of discovering transcripts that have not been annotated in current *** the distribution of RNASeq signals and a systematic view on the potential new transcripts revealed from the signals is an important step toward the understanding of transcriptomes.