Adipocytokines and psoriasis: Insights into mechanisms linking obesity and inflammation to psoriasis

作     者：Maria Dalamaga Evangelia Papadavid 

作者机构：Department of Clinical BiochemistryMedical SchoolUniversity of Athens"Attikon" General University HospitalChaidari12462 AthensGreece Department of DermatologyMedical SchoolUniversity of Athens"Attikon" General University HospitalChaidari12462 AthensGreece 

出 版 物：《World Journal of Dermatology》 (世界皮肤病学杂志)

年 卷 期：2013年第2卷第4期

页      面：27-31页

学科分类：10[医学] 

主　　题：Psoriasis Adipocytokine Obesity Leptin Adiponectin Omentin Resistin Visfatin 

摘      要：Psoriasis has been lately seen as a potential systemic inflammatory disease associated with a range of comorbidities exhibiting an overlapping pathology and presenting a great social health impact such as cardiovascular disease and metabolic diseases,including obesity.Adipose tissue is considered a genuine endocrine organ producing a variety of bioactive adipocytokines,like leptin,adiponectin,resistin and visfatin,participating in physiological and pathological processes,such as energy balance,insulin sensitivity and resistance,immunity,inflammation,hematopoiesis and angiogenesis.Adipocytokines could serve as a missing link in the association between psoriasis,obesity and metabolic co-morbidities.In chronic inflammatory disease states such as psoriasis,adipocytokines may be implicated in psoriasis onset,progression,severity as well as in the pathogenesis of co-morbidities.Measuring serum adipocytokine levels in the future may be useful in predicting psoriasis severity,progression,treatment outcome and risk of any co-mor-bidities.Interventions to decrease pro-inflammatory adipocytokine levels could offer preventive and therapeutic options for improving psoriasis severity and protecting against its co-morbidities.Candidate strategic interventions incorporate increased physical activity,weight control and pharmacologic approaches such as metformin.However,the mechanisms underlying the actions of adipocytokines in psoriasis as well as their potential diagnostic,prognostic and/or therapeutic utility require further investigation with larger prospective,longitudinal and mechanistic studies.