Role of plasmapheresis in early allograft dysfunction following deceased donor liver transplantation

作     者：Ashwin Rammohan Deepti Sachan Satish Logidasan Jeswanth Sathyanesan Ravichandran Palaniappan Mohamed Rela 

作者机构：Institute of Liver Disease and TransplantationGlobal Hospitals and Health City Institute of Surgical Gastroenterology and Liver TransplantationGovt Stanley Medical College Hospital Institute of Liver StudiesKing’s College Hospital 

出 版 物：《World Journal of Hematology》 (世界血液学杂志)

年 卷 期：2017年第6卷第1期

页      面：24-27页

学科分类：10[医学] 

主　　题：Liver transplantation Allograft dysfunction Plasmapheresis 

摘      要：The role of plasmapheresis in liver failure and hepatic encephalopathy is undefined and its use as a strategy to salvage patients with severe allograft dysfunction after liver transplantation remains investigational. We present a case of early allograft dysfunction following deceased donor liver transplantation(DDLT) where plasmapheresis was effective as a bridge to recovery and possibly avoiding a retransplantation. A 16 years old boy, known to have decompensated Wilson s disease underwent DDLT at our Public Sector Hospital. He received a healthy liver from a brain-dead donor, whose liver was considered too large for the boy. The graft was reduced in situ to a left lobe graft. Surgery was uneventful and the recipient was well for the initial 96 h. On Doppler and further computed tomography scan, a partial portal vein thrombus was noted. He was reexplored and a Fogarty endothombecteomy was performed. Following the second surgery, he developed severe allograft dysfunction with a peak bilirubin of 40 mg/d L. He underwent imaging to rule out technical causes for the dysfunction, followed by a liver biopsy, which revealed acute cellular rejection. Multiple cycles of plasmapheresis were initiated. Over the next two weeks, the graft demonstrated a gradual recovery. He was discharged on the 30 th postoperative day, with a serum bilirubin of 5.5 mg/d L. He remains well on follow-up, with the liver function tests improving further. Our report demonstrates the beneficial effect of plasmapheresis, which appears to be an effective treatment option for early allograft dysfunction following liver transplantation and may obviate the need for retransplantation.