Glomus tumors of the fingers:Expression of vascular endothelial growth factor

作     者：Sittisak Honsawek Pravit Kitidumrongsook Pobe Luangjarmekorn Kawee Pataradool Voranuch Thanakit Adisorn Patradul 

作者机构：Vinai Parkpian Orthopaedic Research CenterDepartment of OrthopaedicsFaculty of MedicineChulalongkorn UniversityKing Chulalongkorn Memorial Hospital Department of BiochemistryFaculty of MedicineChulalongkorn University Department of PathologyFaculty of MedicineChulalongkorn University 

出 版 物：《World Journal of Orthopedics》 (世界骨科杂志（英文版）)

年 卷 期：2016年第7卷第12期

页      面：843-846页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Glomus tumors Fingers Vascular endotheligrowth factor 

摘      要：Glomus tumors are uncommon,benign,small neuro-vascular neoplasms derived from glomus bodies in the reticular dermis. Glomus bodies are found throughout the body to regulate body temperature and skin circulation; however,they are concentrated in the fingers and the sole of the foot. The typical presentation is a solitary nodule in the subungual or periungual area of the distal phalanx. The primary treatment of choice is surgical removal. We investigated expression of vascular endothelial growth factor(VEGF) using immunohistochemistry in glomus tumors of the fingers. All five glomus tumor samples were positive for VEGF expression. VEGF immunoreactivity was largely localized to the cytoplasm of tumor cells,suggesting a contribution of VEGF to the vascularization of glomus tumors.