Brain-lung crosstalk: Implications for neurocritical care patients
Brain-lung crosstalk: Implications for neurocritical care patients作者机构：Anesthesiology and Critical Care Department Equipe d’accueil "Modélisation de l’agression tissulaire et nociceptive" University Hospital of Toulouse Department of Anesthesiology and Critical Care Medicine Estaing Hospital University Hospital of Clermont-Ferrand
出 版 物：《World Journal of Critical Care Medicine》 (世界重症医学杂志)
年 卷 期：2015年第4卷第3期
页 面：163-178页
学科分类：1011[医学-护理学（可授医学、理学学位）] 10[医学]
主 题：Brain-lung crosstalk Brain injury Lung injury Protective ventilation Double hit model
摘 要：Major pulmonary disorders may occur after brain injuries as ventilator-associated pneumonia, acute respiratory distress syndrome or neurogenic pulmonary edema. They are key points for the management of brain-injured patients because respiratory failure and mechanical ventilation seem to be a risk factor for increased mortality, poor neurological outcome and longer intensive care unit or hospital length of stay. Brain and lung strongly interact via complex pathways from the brain to the lung but also from the lung to the brain. Several hypotheses have been proposed with a particular interest for the recently described double hit model. Ventilator setting in brain-injured patients with lung injuries has been poorly studied and intensivists are often fearful to use some parts of protective ventilation in patients with brain injury. This review aims to describe the epidemiology and pathophysiology of lung injuries in brain-injured patients, but also the impact of different modalities of mechanical ventilation on the brain in the context of acute brain injury.
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