Caffeine therapy in preterm infants

作     者：Hesham Abdel-Hady Nehad Nasef Abd Elazeez Shabaan Islam Nour 

作者机构：Neonatal Intensive Care UnitMansoura University Children's Hospital 

出 版 物：《World Journal of Clinical Pediatrics》 (世界临床儿科杂志)

年 卷 期：2015年第4卷第4期

页      面：81-93页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Apnea Caffeine Preterm Methylxanthines 

摘      要：Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its effect has been well established in reducing the frequency of apnea, intermittent hypoxemia, and extubation failure in mechanically ventilated preterm infants. Evidence for additional short-term benefits on reducing the incidence of bronchopulmonary dysplasia and patent ductus arteriosus has also been suggested. Controversies existamong various neonatal intensive care units in terms of drug efficacy compared to other methylxanthines, dosage regimen, time of initiation, duration of therapy, drug safety and value of therapeutic drug monitoring. In the current review, we will summarize the available evidence for the best practice in using caffeine therapy in preterm infants.