Bone fragility in type 2 diabetes mellitus

作     者：Toru Yamaguchi 

作者机构：Internal Medicine 1Shimane University Faculty of MedicineShimane 693-8501Japan 

出 版 物：《World Journal of Orthopedics》 (世界骨科杂志（英文版）)

年 卷 期：2010年第1卷第1期

页      面：3-9页

学科分类：10[医学] 

主　　题：Osteoporosis Type 2 diabetes mellitus Fracture risk Osteocalcin Wnt signaling 

摘      要：The number of patients with osteoporosis or type 2 diabetes mellitus(T2DM)is increasing in aging and westernized *** disorders predispose elderly people to disabling conditions by causing fractures and vascular complications,*** is well documented that bone metabolism and glucose/fat metabolism are etiologically related to each other through osteocalcin action and Wnt *** fragility in T2DM,which is not reflected by bone mineral density(BMD),depends on bone quality deterioration rather than bone mass ***,surrogate markers are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM ***,the endogenous secretory receptor for advanced glycation endproducts,and insulin-like growth factor-I seem to be such candidates,although further studies are required to clarify whether or not these markers could predict the occurrence of new fractures of T2DM patients in a prospective fashion.