Metabolic syndrome and chronic kidney disease:Current status and future directions

作     者：G V Ramesh Prasad 

作者机构：Department of MedicineUniversity of Toronto 

出 版 物：《World Journal of Nephrology》 (世界肾病学杂志（英文版）)

年 卷 期：2014年第3卷第4期

页      面：210-219页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Metabolic syndrome Cardiovascular disease Diabetes Dialysis Hyperlipidemia Hypertension Microalbuminuria Obesity Progression 

摘      要：Metabolic syndrome(Met S) is a term used to denote a combination of selected,widely prevalent cardiovascular disease(CVD)-related risk *** the ambiguous definition of Met S,it has been clearly associated with chronic kidney disease markers including reduced glomerular filtration rate,proteinuria and/or microalbuminuria,and histopathological markers such as tubular atrophy and interstitial ***,the etiological role of Met S in chronic kidney disease(CKD) is less *** relationship between MetS and CKD is complex and bidirectional,and so is best understood when CKD is viewed as a common progressive illness along the course of which MetS,another common disease,may intervene and *** mechanisms of renal injury include insulin resistance and oxidative stress,increased proinflammatory cytokine production,increased connective tissue growth and profibrotic factor production,increased microvascular injury,and renal *** also portends a higher CVD risk at all stages of CKD from early renal insufficiency to end-stage renal *** interventions for MetS in the presence of CKD should include a combination of weight reduction,appropriate dietary modification and increase physical activity,plus targeting of individual CVD-related risk factors such as dysglycemia,hypertension,and dyslipidemia while conforming to relevant national societal guidelines.