Acute renal artery occlusion following infliximab infusion

作     者：Caroline Lemaitre Isabelle Iwanicki-Caron Clément De Vecchi Nathalie Bertiaux-Vandaёle Guillaume Savoye 

作者机构：Department of GastroenterologyRouen University Hospital76031 RouenFrance Department of RadiologyRouen University Hospital76031 RouenFrance Institut National de la santé et de la recherche médicale (INSERM) U1073Rouen University Hospital76031 RouenFrance 

出 版 物：《World Journal of Nephrology》 (世界肾病学杂志（英文版）)

年 卷 期：2013年第2卷第3期

页      面：90-93页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Ulcerative colitis Acute renal artery occlusion Infiximab Anti-tumor necrosis factor agent 

摘      要：We report the case of a 44-year-old male patient who presented with acute renal artery occlusion, 3 d after frst injection of infiximab for steroid refractory attack of ulcerative colitis. Extensive work-up provided no evidence of predisposing factors for arterial thrombosis. Infiximab was thus suspected in the genesis of throm-bosis, based on both intrinsic and extrinsic criteria. At month 3 after thrombosis with ongoing anticoagulation, angio-tomodensitometry showed complete revascularization of the left renal artery with renal atrophy. Renal function remained normal and the patient was still in steroid free remission on mercaptopurin monotherapy at maximal follow-up. Few thromboembolic events have been described with anti- tumor necrosis factor （TNF） agents, but it is the frst case reported of renal artery thrombosis after infiximab infusion. In addition, we re-view thrombosis associated with anti-TNF agents.