Brain-derived neurotrophic factor levels in first episode of psychosis:A systematic review

作     者：Alba Toll Anna Mané 

作者机构：Institut de Neuropsiquitria i AddiccionsParc de Salut Mar08003 BarcelonaSpain Fundació Institut Mar d’Investigacions MédiquesHospital del Mar08003 BarcelonaSpain Centro de Investigación Biomédica en Red de Salud Mental08003 BarcelonaSpain 

出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)

年 卷 期：2015年第5卷第1期

页      面：154-159页

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：Brain-derived neurotrophic factor Psychosis 

摘      要：AIM: To systematically review studies measuring peripheric brain-derived neurotrophic factor(BDNF) levels on first-episode psychosis patients and variables related to ***: A systematic search was made of articles published in the Medline database from 2002 up to June 2014. Included are original studies that report enzyme-linked immunosorbent assay measurement of BDNF levels in serum or plasma in patients with a diagnosis of first episode psychosis(FEP) and age- and gender- matched healthy ***: Of the initially identified 147 articles, only 18 satisfied the inclusion criteria. Of this, 15 found a significant reduction in patients with FEP compared with age- and gender- matched controls. CONCLUSION: Peripheral BDNF levels are generally reduced in FEP patients. There are some factors that may influence BDNF levels that need to be further studied. Furthermore, a future meta-analysis in this topic is needed.