Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

作     者：Xiao-rui Zhang Wen-xia Zhou Yong-xiang Zhang 

作者机构：State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2019年第6卷第1期

页      面：78-88页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by the Grants from Chinese Scientific and Technological Major Special Project(2015ZX09J15104002–002 2016ZX09J16104) 

主　　题：Catalytic antioxidant Metalloporphyrins Chemical warfare agent Radiation damage Pharmacodynamics Pharmacokinetics 

摘      要：AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase(SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard(SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome(ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM,chlorine gas and radiation exposure studies.