Voyage inside the cell:Microsystems and nanoengineering for intracellular measurement and manipulation
作者机构：Department of Mechanical and Industrial EngineeringUniversity of Toronto5 King’s College RoadTorontoON M5S 3G8Canada
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2015年第1卷第1期
页 面：82-96页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：atomic force microscopy(AFM) fluorescent proteins and molecules intracellular manipulation intracellular measurement MEMS nanoparticle nanotube nanowire
摘 要：Properties of organelles and intracellular structures play important roles in regulating cellular functions,such as gene expression,cell motility and *** ability to directly interrogate intracellular structures inside a single cell for measurement and manipulation has significant implications in the understanding of subcellular and suborganelle activities,diagnosing diseases,and potentially developing new therapeutic *** the past few decades,a number of technologies have been developed to study single-cell ***,methods of measuring intracellular properties and manipulating subcellular structures have been largely *** to the even smaller size of intracellular targets and lower signal-to-noise ratio than that in wholecell studies,the development of tools for intracellular measurement and manipulation is *** paper reviews emerging microsystems and nanoengineered technologies for sensing and quantitative measurement of intracellular properties and for manipulating structures inside a single *** progress and limitations of these new technologies as well as new discoveries and prospects are discussed.
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