整合素与心血管疾病

作     者：王华 斯琴 

作者机构：中国医学科学院基础医学研究所中国协和医科大学基础医学院病理生理室北京100005 

出 版 物：《中国病理生理杂志》 (Chinese Journal of Pathophysiology)

年 卷 期：2001年第17卷第4期

页      面：366-369页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：国家自然科学基金!重点项目 (No .39730 2 2 0 ) 

主　　题：结合素类 心血管疾病 血管内皮细胞 白细胞粘附 

摘      要：The adhesion of cells to each other and to the proteins of the extracellular matrix provides a stable environment for cell growth, differentiation and migration. This is a prerequisite for the normal function of the cardiovascular system. Thus the abnormal adhesion function may play a key role in the pathogenesis and development of cardiovascular diseases. To date, there are six main groups of adhesion molecule, and integrins family are the largest and most broadly distributed of the families of cellular adhesion receptors. They have an important role in several aspects of cardiovascular diseases and that its regulated inhibition leads to a reduction in incidence and mortality due to these disorders. This review focuses upon the structure、mechanism and their roles in cardiovascular diseases which maybe facilitate the development of novel therapies.