Design rules for a tunable merged-tip microneedle
作者机构：School of Mechanical and Aerospace EngineeringSeoul National UniversitySeoul 08826South Korea Division of WCU Multiscale Mechanical DesignSeoul National UniversitySeoul 08826South Korea Institute of Advanced Machinery and DesignSeoul National UniversitySeoul 08826South Korea Interdisciplinary Program for BioengineeringSeoul National UniversitySeoul 08826South Korea Department of ChemistrySeoul National UniversitySeoulSouth Korea
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2018年第4卷第1期
页 面：85-94页
核心收录：
学科分类：08[工学] 0802[工学-机械工程] 080201[工学-机械制造及其自动化]
基 金：This work was supported by the National Research Foundation and funded by the Ministry of Education of Korea(NRF-2018R1A2A1A05019550,NRF-2016M3A9B4917321,and NRF-2016R1A4A1010796) the Korean Technology R&D Project,Ministry of Health&Welfare,Republic of Korea(HN14C0090)
主 题：microstructure needle cavity
摘 要：This publication proposes the use of an elasto-capillarity-driven self-assembly for fabricating a microscale merged-tip structure out of a variety of biocompatible UV-curable polymers for use as a microneedle *** addition,the novel merged-tip microstructure constitutes a new class of microneedles,which incorporates the convergence of biocompatible polymer micropillars,leading to the formation of a sharp tip and an open cavity capable of both liquid trapping and volume *** combined with biocompatible photopolymer micropillar arrays fabricated with photolithography,elasto-capillarity-driven self-assembly provides a means for producing a complex microneedle-like structure without the use of micromolding or *** publication also explores and defines the design rules by which several fabrication aspects,such as micropillar dimensions,shapes,pattern array configurations,and materials,can be manipulated to produce a customizable microneedle array with controllable cavity volumes,fracture points,and merge *** addition,the incorporation of a modular through-hole micropore membrane base was also investigated as a method for constitutive payload delivery and fluid-sampling *** flexibility and fabrication simplicity of the merged-tip microneedle platform holds promise in transdermal drug delivery applications.
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