Silphiperfolene-Type Terpenoids and Other Metabolites from Cultures of the Tropical Ascomycete Hypoxylon rickii(Xylariaceae)

作     者：Frank Surup Eric Kuhnert Elena Liscinskij Marc Stadler 

作者机构：Department Microbial DrugsHelmholtz Centre for Infection Research GmbHInhoffenstraße 738124 BraunschweigGermany 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2015年第5卷第3期

页      面：167-173页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：His collection trip in Martinique has benefited from“Investissements d’Avenir”Grants of the ANR(CEBA ANR-10-LABX-0025 CNRS Cayenne and Toulouse) 

主　　题：Hypoxylon Xylariaceae Natural products Secondary metabolites Structure elucidation 

摘      要：A culture isolated from ascospores of Hypoxylon rickii,a xylariaceous ascomycete collected in Martinique,had yielded botryane,noreremophilane and abietane-type terpenoids in a preceding study,but additional metabolites were detected by extensive HPLC–MS analysis in other *** we report the further isolation of four new sesquiterpenoids with a silphiperfol-6-ene skeleton from extracts of *** planar structures were elucidated by NMR and HRMS data as 13-hydroxysilphiperfol-6-ene(1),9-hydroxysilphiperfol-6-en-13-oic acid(2),2-hydroxysilphiperfol-6-en-13-oic acid(3)and 15-hydroxysilphiperfol-6-en-13-oic acid(4).For compounds 2–4 we propose the trivial names rickinic acids A–*** stereochemistry was assigned by ROESY correlations as well as by the specific optical ***tionally,the known compounds,botryenanol,dehydrobotrydienol,cyclo(Phe-Pro),cyclo(Pro-Leu),(?)-ramulosin and aeleostearic acid were *** antimicrobial and cytotoxic activities of the new compounds are also reported.