A perspective study and financial analysis of different protocols of second trimester maternal serum screening for Down's syndrome

作     者：戚红 王燕 卢新 刘敏 Qi Hong Wang Yan Lu Xin Liu Min Prenatal screening center,Haidian Maternal & Children Health Hospital,Beijing 100080,China

作者机构：Prenatal screening centerHaidian Maternal & Children Health Hospital 

出 版 物：《生殖医学杂志》 (Journal of Reproductive Medicine)

年 卷 期：2010年第19卷第A2期

页      面：15-19页

学科分类：0710[理学-生物学] 120202[管理学-企业管理（含：财务管理、市场营销、人力资源管理）] 12[管理学] 1202[管理学-工商管理] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

主　　题：唐氏综合征 财务分析 人绒毛膜促性腺激素 血清 筛查 孕妇 透视图 指标测试 

摘      要：Objective:To compare the efficiency and related financial parameters of the double- and triple-marker test for the second-trimester maternal serum screening for Down s syndrome. Methods:The serum samples were collected from the 2^(nd) trimester pregnant women in this hospital and were examined for three biomedical markers[alpha-fetoprotein(AFP),freeβ-human chorionic gonadotropin(freeβ-hCG) and unconjugated estriol(uE_3)]by *** pregnancy outcomes were followed up and screening efficiency calculated for double-marker(AFP+freeβ-hCG) and triple-marker(AFP+ freeβ-hCG+uE_3) test. Results:(1)A total of 4,707 serum samples of 2^(nd) trimester pregnancy were collected in this study,of which 4,245 pregnancy outcomes got followed up by May 30,2009,with 462 cases lost to *** follow-up rate was 90.2%.3 cases of Down s syndrome,4 cases of other chromosome abnormalities and 1 case of neural tube defect (NTD) were *** was no medically induced miscarriage by invasive tests.(2) Detection rate and false positive rate of triple marker test for Down s syndrome screening were 66.7%and 5.26%,respectively,while those in double marker test were 33.3%and 4.01%,*** detection rate of all chromosome abnormalities was 75%in triple marker test and 37.5%in double marker *** detection rate of NTD was 100%either in double or triple marker test.(3) It costs 499,375 RMB to avoid one Down s syndrome birth by using triple marker test and 781,200 RMB by using double marker test. Conclusion:Triple-marker test is superior to double marker test in 2nd trimester maternal serum screening for Down s syndrome,and costs less to avoid a Down s syndrome birth.