Fully integrated wearable impedance cytometry platform on flexible circuit board with online smartphone readout
作者机构：Department of Electrical and Computer EngineeringRutgersThe State University of New JerseyNew BrunswickUSA
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2018年第4卷第1期
页 面：234-243页
核心收录：
学科分类：0401[教育学-教育学] 04[教育学] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 0817[工学-化学工程与技术] 0807[工学-动力工程及工程热物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0811[工学-控制科学与工程] 0702[理学-物理学]
基 金：This work was partially funded by the National Science Foundation Instrumentation Development for Biological Research Grant award number 1556253 also partially by the PhRMA foundation
摘 要：We present a wearable microfluidic impedance cytometer implemented on a flexible circuit wristband with on-line smartphone readout for portable biomarker counting and *** platform contains a standard polydimethylsiloxane(PDMS)microfluidic channel integrated on a wristband,and the circuitry on the wristband is composed of a custom analog lock-in amplification system,a microcontroller with an 8-bit analog-to-digital converter(ADC),and a Bluetooth module wirelessly paired with a *** lock-in amplification(LIA)system is implemented with a novel architecture which consists of the lock-in amplifier followed by a high-pass filter stage with DC offset subtraction,and a post-subtraction high gain stage enabling detection of particles as small as 2.8μm using the 8-bit *** Android smartphone application was used to initiate the system and for offline data-plotting and peak counting,and supports online data readout,analysis,and file *** data is exportable to researchers and medical professionals for in-depth analysis and remote health *** system,including the microfluidic sensor,microcontroller,and Bluetooth module all fit on the wristband with a footprint of less than 80 *** demonstrate the ability of the system to obtain generalized blood cell counts;however the system can be applied to a wide variety of biomarkers by interchanging the standard microfluidic channel with microfluidic channels designed for biomarker isolation.
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