Impact of the number of examined lymph nodes on outcomes in patients with lymph node-negative gallbladder carcinoma
Impact of the number of examined lymph nodes on outcomes in patients with lymph node-negative gallbladder carcinoma作者机构：Department of Vascular surgery First Affiliated Hospital of Jiamusi University Department of Vascular Surgery Shandong Provincial Qianfoshan Hospital Shandong University Department of Medical Oncology Xuzhou Central Hospital The Affiliated Xuzhou Hospital of Medical College of Southeast University Department of Surgery Tianjin Second People's Hospital Department of Breast Surgery Xuzhou Central Hospital The Affiliated Xuzhou Hospital of Medical College of Southeast University
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2018年第24卷第26期
页 面：2886-2892页
核心收录：
主 题：Gallbladder carcinoma Lymph node N0 stage Prognostic factor
摘 要：AIM To determine whether the number of examined lymph nodes(LNs) is correlated with the overall survival of gallbladder carcinoma(GBC) patients. METHODS Patients were collected from the Surveillance Epidemiology and End Results database(2004-2013) and categorized by the number of LNs into six groups: 1 LN, 2 LNs, 3 LNs, 4 LNs, 5 LNs, and ≥ 6 LNs. Survival curves for overall survival were plotted with a KaplanMeier analysis. The log-rank test was used for univariate comparisons.RESULTS In a cohort of 893 patients, the median number of examined LNs was two for the entire cohort. The survival for the 1 LN group was significantly poorer than those of the stage Ⅰ and Ⅱ disease groups and for the entire cohort. By dichotomizing the number of LNs from 1 to 6, we found that the minimum number of LNs that should be examined was four for stage Ⅰ, four or five for stage Ⅱ, and six for stage ⅢA disease. Therefore, for the entire cohort, the number of examined LNs should be at least six, which is exactly consistent with the American Joint Committee on Cancer criteria.CONCLUSION The examination of higher numbers of LNs is associated with improved survival after resection surgery for N0 GBC. The guidelines for GBC surgery, which recommend that six LNs be examined at least, are statistically valid and should be applied in clinical practice widely.
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