Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis
Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis作者机构：Department of Hepatopancreatobiliary Surgerythe Third Affiliated Hospital of Zunyi Medical University Diagnostics LaboratoryAffiliated Hospital of Zunyi Medical University Department of Hepatopancreatobiliary SurgeryAffiliated Hospital of Zunyi Medical University
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2018年第6卷第11期
页 面：441-446页
核心收录：
基 金：Supported by the Fund from the Guizhou Provincial Department of Health Science and Technology,No.GZWJKJ2014-2-151 the Science and Technology Fund of Guizhou Province,No.QKHLH7421 Zunyi Science and Technology Research and Development Fund,No.ZSKHS06
主 题：Carbohydrate antigen 199 Tumor marker Choledocholithiasis Inflammatory marker Diagnosis Acute cholangitis
摘 要：AIM To investigate the diagnostic value of abnormal serum carbohydrate antigen 199(CA199) level in acute cholangitis secondary to choledocholithiasis.METHODS In this retrospective cohort study, the clinical data of 727 patients with choledocholithiasis admitted to the Third Affiliated Hospital of Zunyi Medical College from June 2011 to June 2017 were collected. Among these patients, 258 patients had secondary acute cholangitis and served as observation group, and the remaining 569 choledocholithiasis patients served as the control group. Serum liver function indexes and tumor markers were detected in both groups, and the receiver operating characteristic(ROC) curves were constructed for markers showing statistical significances. The cutoff value, sensitivity, and specificity of each marker were calculated according to the ROC curves. RESULTS The results of liver function tests showed no significant differences between the two groups(P 0.05). Tumor markers including serum CA125, CA153, carcinoembryonic antigen, and alpha fetoprotein levels were also not significantly different(P 0.05); however, the serum CA199 level was significantly higher in the observation group than in the control group(P 0.05). The ROC curve analysis showed that the area under the curve was 0.885(95%CI: 0.841-0.929) for CA199, and the cutoff value of 52.5 kU/L had the highest diagnostic accuracy, with a sensitivity of 86.8% and a specificity of 81.6%.CONCLUSION Abnormally elevated serum CA199 level has an important value in the diagnosis of acute cholangitis secondary to choledocholithiasis. It may be a specific inflammatory marker for acute cholangitis.
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