Current state of renal transplant immunosuppression:Present and future
Current state of renal transplant immunosuppression: Present and future作者机构：Department of Pharmaceutical SciencesSchool of PharmacyUniversity of PittsburghPittsburghPA 15260United States Karen L HardingerDepartment of Pharmacy Practice and AdministrationUniversity of Missouri-Kansas CityKansasMO 64108United States
出 版 物：《World Journal of Transplantation》 (世界移植杂志)
年 卷 期：2012年第2卷第4期
页 面：51-68页
学科分类：10[医学]
主 题：Review Immunosuppression Investigational agents Renal/kidney transplant
摘 要：For kidney transplant recipients, immunosuppression commonly consists of combination treatment with a calcineurin inhibitor, an antiproliferative agent and a corticosteroid. Many medical centers use a sequential immunosuppression regimen where an induction agent, either an anti-thymocyte globulin or interleukin-2 receptor antibody, is given at the time of transplantation to prevent early acute rejection which is then followed by a triple immunosuppressive maintenance regimen. Very low rejection rates have been achieved at many transplant centers using combinations of these agents in a variety of protocols. Yet, a large number of recipients suffer chronic allograft injury and adverse events associated with drug therapy. Regimens designed to limit or eliminate calcineurin inhibitors and/or corticosteroid use are actively being pursued. An ideal immunosuppressive regimen limits toxicity and prolongs the functional life of the graft. This article contains a critical analysis of clinical data on currently available immuno-suppressive strategies and an overview of therapeutic moieties in development.
维普期刊数据库