Effects of Electroacupuncture on Expressions of Angiogenesis Factors and Anti-angiogenesis Factors in Brain of Experimental Cerebral Ischemic Rats after Reperfusion

作     者：马璟曦 罗勇 王友京 

作者机构：The First Affiliated HospitalChongqing University of Medical Sciences 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2008年第28卷第3期

页      面：217-222页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学] 

主　　题：电针刺 治疗 实验 医学 

摘      要：Objective:To explore the mechanism of electroacupuncture(EA) in improving ischemic ***:The Wistar rat model of focal cerebral ischemia-reperfusion was prepared by the thread embolism *** rats were randomly divided into a normal group,a model group,and an EA *** was given at bilateral Hegu(LI 4) in rats of the EA *** of the vascular endothelial growth factor(VEGF) mRNA was detected with hybridization in situ,and expressions of the angiogenin-1(Ang-1) and endostatin proteins were detected with the immunohistochemical ***:As compared with the normal group,the expressions of VEGF mRNA,Ang-1 protein and endostatin protein significantly increased in the model group(all P0.05);and when compared with the model group,the EA group showed even more significant increase in expressions of the VEGF mRNA and Ang-1 protein(both P0.05),but with an obvious decline in the increase of expression of endostatin protein(P0.05).Conclusions:EA can promote angiogenesis in brain of experimental cerebral ischemic rats after reperfusion probably through up-regulating the expression of angiogenesis factors and down-regulating the expression of anti-angiogenesis factors.