Mycophenolate mofetil toxicity mimicking acute cellular rejection in a small intestinal transplant
Mycophenolate mofetil toxicity mimicking acute cellular rejection in a small intestinal transplant作者机构：Australian Intestinal Transplant Service Austin Health
出 版 物：《World Journal of Transplantation》 (世界移植杂志)
年 卷 期：2017年第7卷第1期
页 面：98-102页
学科分类：10[医学]
主 题：Small intestinal transplantation Drug toxicity Mycophenolate mofetil Acute cellular rejection Immunosuppression
摘 要：Mycophenolate mofetil(MMF) is an important medication used for maintenance immunosuppression in solid organ transplants. A common gastrointestinal(GI) side effect of MMF is enterocolitis, which has been associated with multiple histological features. There is little data in the literature describing the histological effects of MMF in small intestinal transplant(SIT) recipients. We present a case of MMF toxicity in a SIT recipient, with histological changes in the donor ileum mimicking persistent acute cellular rejection(ACR). Concurrent biopsies of the patient s native colon showed similar changes to those from the donor small bowel, suggesting a non-graft specific process, raising suspicion for MMF toxicity. The MMF was discontinued and complete resolution of these changes occurred over three weeks. MMF toxicity should therefore be considered as a differential diagnosis for ACR and graftversus-host disease in SITs.
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