Cathepsin D: Autoantibody profiling as a diagnostic marker for cancers

作     者：Vaclav Vetvicka Martin Fusek 

作者机构：Department of PathologyUniversity of LouisvilleLouisvilleKY 40202United States Department of Biochemistry and MicrobiologyInstitute of Chemical Technology166 28 PragueCzech Republic 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2013年第4卷第1期

页      面：1-3页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cathepsin D Procathepsin D Autoantibodies Diagnosis Marker 

摘      要：Current diagnostic assays for many cancers are antigen-based and rely on the detection of circulating proteins that are associated with a particular *** assays depend on the expression,synthesis,and release of specific proteins by cells(e.g.,tumor cells)through either active secretion or shedding,or as a consequence of cell death(either necrosis or apoptosis).As such,these antigenic proteins must“escapethe primary site of disease,saturate the antigen-processing capacity of the individual’s immune components,gain access to the circulation,and reach a sufficient steady-state concentration to be detected by enzyme-or radiolabel-based *** events usually occur after the initial establishment of ***,and despite the fact that certain specific antigenic epitopes exhibit common recognition among patients with the same tumor types,the use of these antigen-based cancer assays has not been widely accepted in clinical practice,and many individual countries differ in the use of these potential diagnostic ***,an increasing number of studies demonstrated that procathepsin D secreted from cancer cells,acts as a mitogen on cancer cells and stimulates their pro-invasive and pro-metastatic *** this report,we focused on the possibility to use antiprocathepsin D autoantibodies as a diagnostic and/or predictive marker for cancers.