An efficient chiral synthesis of (R)-N-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl]-butanamide with high enantioselectivity

作     者：WANG NaiXing1,2 & TANG XinLiang1,3 1 Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100080,China 2 College of Chemistry and Chemical Engineering,Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 School of Chemical Engineering and Environment,Beijing Institute of Technology,Beijing 100081,China 

作者机构：Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing China College of Chemistry and Chemical Engineering Graduate University of Chinese Academy of Sciences Beijing China School of Chemical Engineering and Environment Beijing Institute of Technology Beijing China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2009年第52卷第8期

页      面：1216-1219页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by the National Natural Science Foundation of China (Grant Nos. 20472090 & 10576034) PLA General Armament Department (Grant No. 9140A28010707zk7301) 

主　　题：chiral synthesis enantioselectivity enatiomeric excess chiral HPLC analysis 

摘      要：R-Enantiomer of the β-receptor antagonist N-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl] butanamide with high enantioselectivity was synthesized from cheap starting materials and enantiopure chiral reagent through an efficient,convenient and practical synthetic *** product was detected by 1H NMR,13C NMR,and MS,and the enatiomeric excess was determined by chiral HPLC analysis using a chiracel AD-H column.