CD117 is not always positive in infantile gastrointestinal stromal tumor

作     者：Jin Peng He Jie Xiong Feng 

作者机构：Department of Pediatric SurgeryTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology1095 Jiefang AveQiaokou DistrictWuhan 430030HubeiChina 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2018年第14卷第1期

页      面：100-103页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：CD117 infantile gastrointestinal stromal tumor Gastrointestinal stromal tumors (GISTs) 

摘      要：Gastrointestinal stromal tumors (GISTs) are rare in infants. GIST was presumed to originate from the interstitial cells of Cajal (ICC), which has been proven by their immu-nophenotype (CD117 positive). About 95% of GISTs express CD117 and 80% of GISTs also express CD34. They locate mostly in the stomach or the small intestine and usu-ally cause obstruction (1)The UK National Registry of Childhood Tumors reported the incidence of GISTs at 0.02 per million per year in children below the age of 14 years (2)Here we will discuss a very rare case of infantile GIST with negative CD117 expression and make a review of lit-eratures about its clinical, histopathological, and prognos-tic findings.