Association of gastroesophageal reflux disease and laryngeal cancer

作     者：Mursalin M.Anis Mir-Muhammad Razavi Xiao Xiao Ahmed M.S.Soliman Anis Mursalin M.;Razavi Mir-Muhammad;Xiao Xiao;Soliman Ahmed M.S.

作者机构：Coastal EarNose and ThroatJersey Shore University Medical CenterNeptuneNJUSA Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA Department of StatisticsFox School of BusinessTemple UniversityPhiladelphiaPAUSA Department of Otolaryngology e Head and Neck SurgeryLewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA 

出 版 物：《World Journal of Otorhinolaryngology-Head and Neck Surgery》 (世界耳鼻咽喉头颈外科杂志（英文）)

年 卷 期：2018年第4卷第4期

页      面：278-281页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Laryngopharyngeal reflux GERD Extraesophageal reflux Laryngeal cancer Lung cancer 

摘      要：Objective:Studies examining the association of reflux disease with the risk of developing laryngeal cancer have both proven and disproven the null ***:This retrospective caseecontrol study examines the association of reflux in two populations exposed to similar risk factors,including tobacco,to the extent that end-organ malignant transformation has *** IRB approval was obtained,a search of our hospital’s cancer center’s database was performed from 2000 to 2013.A retrospective chart review was then performed and the prevalence of gastroesophageal reflux disease among patients with laryngeal cancer(n Z 290)was *** was then compared to the prevalence of gastroesophageal reflux disease among patients presenting with lung cancer(n Z 2440)during the same time period.A multivariate logistic regression was performed to determine the association of reflux with laryngeal ***:Taking into consideration tobacco use,there was a strong association between male gender and occurrence of laryngeal cancer as opposed to lung cancer(OR Z 3.30;95%CI 2.53e4.36,P0.001).There was a modest association between reflux and laryngeal cancer(OR Z 1.65;95%CI 1.19e2.25,P Z 0.003).However,there was no association between reflux and the propensity for carcinoma in specific laryngeal subsites(P Z 0.47).Conclusions:In this study examining a heterogeneous population with end-organ malignancy there was a modest association between reflux and laryngeal *** research is necessary to determine the biologic relevance of this finding.