急性高胰岛素血症对肥胖症患者心室复极化的影响

作     者：Iacobellis G. Curione M. Di Bona S. 腾增辉 

作者机构：Center for Human Nutrition University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard Dallas TX 75390-9052United States 

出 版 物：《世界核心医学期刊文摘（心脏病学分册）》 (Digest of the World Core Medical Journals(Cardiology))

年 卷 期：2005年第1卷第7期

页      面：51-51页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：肥胖症患者 高胰岛素血症 心室复极 胰岛素抵抗 胰岛素分泌 血糖正常 离散度 

摘      要：Background: Acute hyperinsulinemia has been shown to increase QTc interval in lean subjects, but data on obese subjects are still unclear. Aim of this study was to evaluate the effect of acute hyperinsulinemia on QTc interval and QTc dispersion in uncomplicated obesity. Methods: We calculated QTc duration and QTc dispersion in 30 uncomplicated obese subjects(mean age 32.2±7, BMI 36.7±9.4 kg/m2) by measurements of 12-lead ECG recording during a euglycemic hyperinsulinemic clamp. Results: Insulin infusion during the clamp did not significantly modify QTc interval and QTc dispersion in uncomplicated obese subjects(401.5±29.2 vs. 413.7±30.5; 35.4±10.5 vs. 38.7±14.5, respectively). Conclusions: Acute hyperinsulinemia seems to no significantly affect ventricular repolarization in uncomplicated obesity. Insulin resistance and the absence of diabetes and hypertension could explain, at least in part, this finding.