Effect of L-Arginine on Pulmonary Artery Smooth Muscle Cell Apoptosis in Rats with Hypoxic Pulmonary Vascular Structural Remodeling

作     者：Ingrid Karmane SUMOU 

作者机构：Beijing 100034.China Department of Pediatrics Peking University First Hospital 

出 版 物：《Acta Biochimica et Biophysica Sinica》 (生物化学与生物物理学报(英文版))

年 卷 期：2006年第38卷第1期

页      面：15-21页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：This work was sopported by the grants from the National Natural Science Foundation of China(30425010 and 30571971) the Major Baslc Research Program of China(G2000056905) 

主　　题：hypoxia pulmonary artery arginine apoptosis 

摘      要：This study investigated the effect of L-arginine (L-Arg) on the apoptosis of pulmonary arterysmooth muscle cells (PASMC) in rats with hypoxic pulmonary vascular structural remodeling,and *** Wistar rats were randomly divided into a control group (n=5),a hypoxia group(n=7),and a hypoxia+L-Arg group (n=5).The morphologic changes of lung tissues were observed underoptical *** the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling assay,the apoptosis of PASMC was *** expression in PASMC wasexamined using *** results showed that the percentage of muscularized artery insmall pulmonary vessels,and the relative medial thickness and relative medial area of the small and medianpulmonary muscularized arteries in the hypoxic group were all significantly *** vascularstructural remodeling developed after *** smooth muscle cells of the small and median pul-monary arteries in the hypoxia group were significantly less than those in the control *** 14 d ofhypoxia,Fas expression by smooth muscle cells of median and small pulmonary arteries was significantlyinhibited.L-Arg significantly inhibited hypoxic pulmonary vascular structural remodeling in association withan augmentation of apoptosis of smooth muscle cells as well as Fas expression in *** resultsshowed that L-Arg could play an important role in attenuating hypoxic pulmonary vascular structural remod-eling by upregulating Fas expression in PASMC,thus promoting the apoptosis of PASMC.