异位性皮炎发病中过敏原引起的IgE依赖性T细胞活化:病理生理学相关性

作     者：Cooper D. Hales J. Camp R. 张宪旗 

作者机构：Dept. Infect. Immun. Inflammation University of Leicester Maurice Shock Med. Sciences Building University Road Leicester LE1 9HN United Kingdom Dr. 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第4期

页      面：23-23页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：异位性皮炎 T细胞活化 IgE 病理生理学 特异性免疫 自体血清 外周血单核细胞 递呈 靶位 于最 

摘      要：The importance of interactions between allergen and IgE in allergen-mediated activation of T lymphocytes from patients with atopic dermatitis (AD) is unclear. A role for this interaction is implied by past evidence for IgE-facilitated presentation of allergen to T cells, but this phenomenon has only been demonstrated in specific in vitro systems biased to maximize the effect. It is therefore not known whether the process is relevant in patients. We now show that the responses to allergen of unmodified peripheral blood mononuclear cells (PBMC)from individual AD patients are significantly greater in the presence of fresh, unheated, IgE-containing autologous serum than the same serum heated under IgE-denaturing conditions or specifically depleted of IgE by immunoprecipitation. In six independent experiments, 59%-67%of the maximal in vitro PBMC response to allergen was found to be dependent upon the presence of IgE in autologous serum used at 5%final concentration. These data provide the first evidence that sufficient amounts of allergen-specific IgE and allergen-reactive T cells occur concomitantly in the blood of individual AD patients to allow IgE-enhanced T cell responses to allergen. We conclude that IgE-enhanced T cell responses are pathophysiologically relevant and a therapeutic target in AD.