拉丁美洲阿尔茨海默病患者出现症状早于英国患者
Earlier onset of Alzheimer disease symptoms in latino individuals compared with anglo individuals作者机构：3615 Chestnut St Philadelphia PA 19104 United States Dr.
出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)
年 卷 期：2005年第1卷第9期
页 面：20-21页
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
主 题：阿尔茨海默病 发病年龄 体格检查 人口统计学 人口增长 评估研究 研究协会 研究中心
摘 要：Background: Latino individuals are the largest minority group and the fastest growing population group in the United States, yet there are few studies comparing the clinical features of Alzheimer disease (AD) in th is population with those found in Anglo (white non-Latino) patients. Objective: To compare the age at AD symptom onset in Latino and Anglo individuals. Design: Cross-sectional assessment using standardized methods to collect and compare a ge at AD symptom onset, demographic variables, and medical variables. Setting: F ive National Institute on Aging-sponsored Alzheimer’s Disease Centers with exp erience evaluating Spanish-speaking individuals. Patients: We evaluated 119 Lat ino and 55 Anglo patients who had a diagnosis of AD. Main Outcome Measure: Age a t symptom onset. Results: After adjusting for center, sex, and years of educatio n, Latino patients had a mean age at symptom onset 6.8 years earlier (95%confid ence interval, 3.5-10.3 years earlier) than Anglo patients. Conclusions: An ear lier age at symptom onset suggests that US mainland Latino individuals may exper ience an increased burden of AD compared with Anglo individuals. The basis for t he younger age at symptom onset remains obscure.
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