Insight to drug delivery aspects for colorectal cancer
Insight to drug delivery aspects for colorectal cancer作者机构：Center for Interdisciplinary ResearchD.Y.Patil UniversityKolhapur 416006MaharashtraIndia Pharmaceutics Research LaboratoryDepartment of PharmaceuticsRavishankar College of PharmacyBhopal 462010Madhya PradeshIndia Pharmaceutics Research Projects LaboratoryDepartment of Pharmaceutical SciencesDr.Hari Singh Gour Central UniversitySagar 470003Madhya PradeshIndia
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2016年第22卷第2期
页 面：582-599页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Colorectal cancer Receptor based targetedtherapy Gene delivery
摘 要：Colorectal cancer(CRC) is the third most common cancer diagnosed worldwide in human beings. Surgery, chemotherapy, radiotherapy and targeted therapiesare the conventional four approaches which are currently used for the treatment of CRC. The site specific delivery of chemotherapeutics to their site of action would increase effectiveness with reducing side effects. Targeted oral drug delivery systems based on polysaccharides are being investigated to target and deliver chemotherapeutic and chemopreventive agents directly to colon and rectum. Site-specific drug delivery to colon increases its concentration at the target site, and thus requires a lower dose and hence abridged side effects. Some novel therapies are also briefly discussed in article such as receptor(epidermal growth factor receptor, folate receptor, wheat germ agglutinin, VEGF receptor, hyaluronic acid receptor) based targeting therapy; colon targeted proapoptotic anticancer drug delivery system, gene therapy. Even though good treatment options are available for CRC, the ultimate therapeutic approach is to avert the incidence of CRC. It was also found that CRCs could be prevented by diet and nutrition such as calcium, vitamin D, curcumin, quercetin and fish oil supplements. Immunotherapy and vaccination are used nowadays which are showing better results against CRC.
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