Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke

作     者：Lianqiu Min Shuai Shao Xiaoning Wu Lin Cong Ping Liu Haiping Zhao Yumin Luo 

作者机构：Department of NeurologyFirst Affiliated Hospital of Liaoning Medical University Department of NeurologyLiaoyang Central Hospital Department of NeurologyFuxin No.2 People's Hospital Research Institute of Cerebrovascular DiseasesXuanwu Hospital of Capital Medical University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第23期

页      面：2144-2154页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Natural Science Foundation of Liaoning Province in China,No.20092192 the National Natural Science Foundation of China,No.81071058 

主　　题：neural regeneration brain injury ischemic strokeC-reactive protein fibrinogen D-dimer inflammationlarge-artery atherosclerosis atorvastatin thrombus triacylglycerol low-density lipo-protein cholesterol grants-supported paper neuroregeneration 

摘      要：Atorvastatin decreases inflammation and thrombogenesis in patients with carotid artery plaque. Atorvastatin is administered to lower lipid levels, but its anti-inflammatory and anti-thrombogenic effects remain unclear. Eighty-nine patients from northeastern China with acute ischemic stroke caused by large-artery atherosclerosis were randomly divided into the study and control groups. All patients received routine treatment, including antiplatelet therapy, circulatory support, and symp- tomatic treatment. The study group （n = 43） also received daily atorvastatin 20 mg/d, and the control group （n = 46） received daily placebo pills containing glucose. After 4 weeks, the levels of C-reactive protein, fibrinogen, and D-dimer were significantly lower in the study group than in the control group. Decreases in the levels of C-reactive protein, fibrinogen, and D-dimer were not associated with de- creases in the levels of triacylglycerol and low-density lipoprotein cholesterol. These results suggest that atorvastatin reduces inflammation and thrombogenesis independent of its lipid-lowering effects in patients with acute ischemic stroke caused by large-artery atherosclerosis.