Mechanism of actions of Oncocin, a proline- rich antimicrobial peptide, in early elongation revealed by single-molecule FRET

作     者：Sijia Peng Mengyi Yang Rui Ning Sun Yang Liu Wenjuan Wang Qiaoran Xi Haipeng Gong Chunlai Chen 

作者机构：School of Life Sciences Tsinghua University Beijing 100084China Tsinghua-Peking Joint Center for Life Sciences Tsinghua Univer-sity Beijing 100084 China Beijing Advanced Innovation Center for Structural Biology Ts-inghua University Beijing 100084 China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084 China Technology Center for Protein Sciences Tsinghua UniversityBeijing 100084 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2018年第9卷第10期

页      面：890-895页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 09[农学] 0903[农学-农业资源与环境] 10[医学] 

基　　金：This project is supported by funds from the National Natural Science Foundation of China Tsinghua-Peking Joint Center for Life Sciences and Beijing Advanced Innovation Center for Structural Biology to CC Lab Innovation Funding from Lab and Instrument Department, Tsinghua University to WW 

主　　题：AMINOACYL-TRANSFER-RNA PROTEIN-SYNTHESIS MAMMALIAN-CELLS RIBOSOME INHIBITION SELECTION 

摘      要：Dear Editor Proline-rich antimicrobial peptides （PrAMPs） are a class of antimicrobial peptides containing a high content of proline residues. PrAMPs selectively target Gram-negative bacteria through special transporters such as SmbA to enter cyto- plasm （Mattiuzzo et al., 2007）. On the other hand, PrAMPs present a low toxicity to mammalian cells, because they cannot effectively penetrate the mammalian cellular mem- brane （Hansen et al., 2012） or they are internalized through an endocytotic process to minimize interaction with cytosolic ribosomes （Tomasinsig et al., 2006）. Therefore, PrAMPs are promising candidates to treat infections and to deliver drugs （Schmidt et al., 2016）.