Plasmonic molecular assays： Recent advances and applications for mobile health

作     者：Tao Yu Qingshan Wei 

作者机构：Department of Chemical and Biomolecular Engineering North Carolina State University 911 Partners Way Campus Box 7905Raleigh NC 27695 USA 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2018年第11卷第10期

页      面：5439-5473页

核心收录：

学科分类：1305[艺术学-设计学（可授艺术学、工学学位）] 13[艺术学] 0808[工学-电气工程] 07[理学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 070301[理学-无机化学] 0702[理学-物理学] 

基　　金：supported by the Chancellor’s Faculty Excellence Program and the Kenan Institute for Engineering  Technology & Science (KIETS) at NC State 

主　　题：plasmonics molecular assay point-of-care diagnostics mobile health imaging sensing 

摘      要：Plasmonics-based biosensing assays have been extensively employed for biomedical applications. Significant advancements in use of plasmonic assays for the construction of point-of-care （POC） diagnostic methods have been made to provide effective and urgent health care of patients, especially in resource- limited settings. This rapidly progressive research area, centered on the unique surface plasmon resonance （SPR） properties of metallic nanostructures with exceptional absorption and scattering abilities, has greatly facilitated the development of cost-effective, sensitive, and rapid strategies for disease diagnostics and improving patient healthcare in both developed and developing worlds. This review highlights the recent advances and applications of plasmonic technologies for highly sensitive protein and nucleic acid biomarker detection. In particular, we focus on the implementation and penetration of various plasmonic technologies in conventional molecular diagnostic assays, and discuss how such modification has resulted in simpler, faster, and more sensitive alternatives that are suited for point-of-use. Finally, integration of plasmonic molecular assays with various portable POC platforms for mobile health applications are highlighted.