S1-4 Chronic Nicot ine Treatment Alleviates Schizophrenia-Induced Memory Deficit through Regulating Pdlim5 and CRTC1 in Mice
作者机构：Soochow Universitysuzhou215021China
出 版 物：《神经药理学报》 (Acta Neuropharmacologica)
年 卷 期：2018年第8卷第4期
页 面：6-7页
主 题：schizophrenia cognitive impairment nicotine Pdlim5 CRTC1
摘 要：Objective:Cognitive impairment is a core deficit of schizophrenia and current antipsychotic treatments have no or only very limited effects on cognitive *** studies have found that about 50%~90%of all psychiatric patients are smokers,and the high rate of smoking may be due to the fact that the patients smoke tobacco to reduce their cognitive *** is the key psychoactive component and various studies have reported that nicotine can improve cognition under some ***,we propose our hypothesis that nicotine alleviates schizophreniainduced cognitive *** published results confirmed that nicotine treatment significantly improved rat’s working memory in the delayed alternate T maze task(DAT).Methods:In this current study,MK-801 was applied to induce schizophrenia-like behavior which was confi rmed by pre-pulse inhibition(PPI)and T-maze used to assess cognitive ***:Our data showed that MK-801 caused cognitive impairment accompanied by an increase of Pdlim5,anadaptor protein that is critically associated with schizophrenia in medial prefrontal cortex(mPFC).Of note,chronic nicotine treatment attenuates MK-801-induced schizophrenia-like symptom as well as cognitive impairment by regulating *** addition,nicotine treatment also reduced MK-801-induced decrease of CREBregulated transcription coactivator 1(CRTC1),a coactivator of CREB which has been shown to play an important role in *** important,MK-801 neither induced schizophrenia-like behavior in pdlim5-/-mice,nor decreased CRTC1 in ***:Our results showed that chronic nicotine treatment alleviates schizophrenia-induced memory defi cit through regulating Pdlim5 and CRTC1 in mice.
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