Oxytocin structure and function in New World monkeys:from pharmacology to behavior
作者机构：Program in Neuroscience and BehaviorUniversity of Nebraska at OmahaOmahaNebraskaUSA
出 版 物：《Integrative Zoology》 (整合动物学（英文版）)
年 卷 期：2018年第13卷第6期
页 面：634-654页
核心收录：
学科分类：0710[理学-生物学] 081704[工学-应用化学] 07[理学] 0905[农学-畜牧学] 08[工学] 0817[工学-化学工程与技术] 0906[农学-兽医学] 070303[理学-有机化学] 0703[理学-化学]
基 金：The work reported here and the preparation of this manuscript are supported in part by funds from the NIH(HD042882 HD089147)
主 题：cell signaling marmoset oxytocin receptor pharmacology social behavior
摘 要：Oxytocin(OT)is a hypothalamic nonapeptide that mediates a host of physiological and behavioral processes in-cluding reproductive physiology and social *** the OT sequence structure is highly conserved among mammals,New World monkeys(NWMs)represent an unusual“hot spotin OT structure variability among *** least 6 distinct OT ligand variants among NWMs exist,yet it is currently unclear whether these evolved structural changes result in meaningful functional *** offer a new area to explore how these modifications to OT and its canonical G-protein coupled OT receptor(OTR)may mediate specific cellular,physiological and behavioral *** this review,we highlight relationships between OT ligand and OTR structural variability,specifically examining coevolution between OT ligands,OTRs,and physiological and behavioral phenotypes across *** consider whether these evolved modifications to the OT structure alter pharmacological profiles at human and marmoset OTRs,including changes to receptor binding,intracellular signaling and receptor ***,we evaluate whether exogenous manipulation using OT variants in marmoset monkeys differentially enhance or impair behavioral processes involved in social relationships between pairmates,opposite-sex strangers,and parents and their ***,it appears that changes to OT ligands in NWMs result in important changes ranging from cellular signaling to broad measures of social behavior.
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