Analysis of risk factors for central venous port failure in cancer patients

作     者：Ching-Chuan Hsieh Hsu-Huei Weng Wen-Shih Huang Wen-Ke Wang Chiung-Lun Kao Ming-Shian Lu Chia-Siu Wang 

作者机构：Division of General Surgery Department of Surgery ChangGung Memorial Hospital Chiayi 613 Taiwan China GraduateInstitute of Clinical Medical Science College of MedicineChang Gung University Taoyuan 333 Taiwan China Department of Diagnostic Radiology ChangGung Memorial Hospital Chiayi 613 Taiwan China Division of Colon and Rectal SurgeryDepartment of Surgery Chang Gung Memorial Hospital Chiayi613 Taiwan China Division of Thoracic andCardiovascular Surgery Department of Surgery Chang GungMemorial Hospital Chiayi 613 Taiwan China Division of General Surgery Department ofSurgery Chang Gung Memorial Hospital Chiayi 613 TaiwanChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第37期

页      面：4709-4714页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：风险因素 端口 静脉 患者 癌症 中央 

摘      要：AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (TIVADs) were implanted into 1280 cancer patients in this cohort study. A Cox proportional hazard model was applied to analyze risk factors for failure of TIVADs. Log-rank test was used to compare actuarial survival rates. Infection, thrombosis, and surgical complication rates (χ2 test or Fisher s exact test) were compared in relation to the risk factors. RESULTS: Increasing age, male gender and openended catheter use were signifi cant risk factors reducing survival of TIVADs as determined by univariate and multivariate analyses. Hematogenous malignancy decreased the survival time of TIVADs; this reduction was not statistically signifi cant by univariate analysis [hazard ratio (HR) = 1.336, 95% CI: 0.966-1.849, P = 0.080)]. However, it became a signifi cant risk factor by multivariate analysis (HR = 1.499, 95% CI: 1.079-2.083, P = 0.016) when correlated with variables of age, sex and catheter type. Close-ended (Groshong) catheters had a lower thrombosis rate than open-ended catheters (2.5% vs 5%, P = 0.015). Hematogenous malignancy had higher infection rates than solid malignancy (10.5% vs 2.5%, P 0.001). CONCLUSION: Increasing age, male gender, openended catheters and hematogenous malignancy were risk factors for TIVAD failure. Close-ended catheters had lower thrombosis rates and hematogenous malignancy had higher infection rates.