The Value of PAPP-A and MMP-9 in the Diagnosis and Outcome of ACS Patients

作     者：Huang Jun Xiao Jing Peng Jingtian Hao Lianman Peng Xiaoping Zhang Zhiliang 

作者机构：Department of Cardiology The First Affiliated Hospital Nanchang University Nanchang 330006 China 

出 版 物：《South China Journal of Cardiology》 (岭南心血管病杂志（英文版）)

年 卷 期：2007年第8卷第2期

页      面：72-75,66页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Acute coronary syndrome PAPP A MMP 9 Hs CRP 

摘      要：Objectives To investigate the value of pregnancy-associated plasma protein-A （ PAPP-A ） and matrix metallo proteinase-9 （MMP-9） in the diagnosis and outcomes evaluation of acute coronary syndrome （ACS） patient. Methods 100 ACS patients were divided into UAP group （ 64 cases ） and AMI group （ 36 cases）, and 50 healthy cases served as control group. The levels of PAPP-A, MMP-9, Hs-CRP, CK-MB and cTnI were obtained. The ACS patients with normal CK-MB and cTnI concentration were followed up. During 6 months, the total rates of major cardiovascular events （MACE） were recorded. Results Compared to control group, the PAPP-A, MMP-9, Hs-CRP, CK-MB, cTnI levels of ACS patients were significantly increased （ P 〈 0.01 ）, but the levels of PAPP-A, MMP-9 did not correlate well with CK-MB and cTnI. The ACS patients with normal CK-MB and cTnI concentration were followed up 6 months, the levels of PAPP-A, MMP-9 were significantly associated with the MACE （ P 〈 0.01 ）. Conclusions The levels of PAPP-A, MMP-9 of ACS patients were not associated with myocardial ischemic necrosis, but could serve as predictor of unstable atherosclerotic plaque, and as valuable index for prognosis monitoring in ACS patients.